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DTSTART;TZID=Europe/Paris:20231107T140000
DTEND;TZID=Europe/Paris:20231107T153000
DTSTAMP:20260422T125628
CREATED:20231102T074310Z
LAST-MODIFIED:20231102T093351Z
UID:9328-1699365600-1699371000@fermi.univ-tlse3.fr
SUMMARY:Instabilities and Geometry of Growing Tissues. - (Doron Grossman  / LPT / Seminar). - 07/11/2023\, 14 H.
DESCRIPTION:Doron Grossman  (LPT) \nSeminar LPT\, 7/11/2023\, 14H\, 3R1\, seminar room\, 3rd floor \nSummary :\nWe present a covariant continuum formulation of a generalized two-dimensional vertexlike model of epithelial tissues which describes tissues with different underlying geometries\, and allows for an analytical macroscopic description. Using a geometrical approach and out-of-equilibrium statistical mechanics\, we calculate both mechanical and dynamical instabilities of a tissue\, and their dependencies on various variables\, including activity\, and cell-shape heterogeneity (disorder). We show how both plastic cellular rearrangements and the tissue elastic response depend on the existence of mechanical residual stresses at the cellular level. Even freely growing tissues may exhibit a growth instability depending on the intrinsic proliferation rate. Our main result is an explicit calculation of the cell pressure in a homeostatic state of a confined growing tissue. We show that the homeostatic pressure can be negative and depends on the existence of mechanical residual stresses. This geometric model allows us to sort out elastic and plastic effects in a growing\, flowing\, tissue. We calculate the rheological response of such a living tissue\, and show that it can exhibit shear thinning\, shear thickening and thixotropic behaviour\, depending on the condition.
URL:https://fermi.univ-tlse3.fr/event/instabilities-and-geometry-of-growing-tissues-doron-grossman-lpt-seminar-07-11-2023-14-h/
LOCATION:salle de séminaire 3ème étage\, Bâtiment 3r1 Université Toulouse III\, Toulouse\, 31400\, France
CATEGORIES:Events,LPT,Seminars
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