Inferring collective behavior from social interactions to population coding. – (Xiaowen Chen / LPT / Seminar). – 17/06/2025, 14H

Séminaire LPT

Xiaowen Chen (LPENS, Paris)

Seminar LPT, 17/06/2025, 14H, 3R4, salle de conférence

Résumé :
From social animals to neuronal networks, collective behavior is ubiquitous in living systems. How are these behaviors encoded in interactions, and how do they drive biological functions? Recent insights from statistical physics applied to biological data have offered exciting new perspectives. However, previous research has mostly focused on the statics, i.e., the steady-state distributions of the collective behavior.

In this talk, I will present two recent progresses tapping into the temporal domain. First, I will present a study of collective behavior in social mice from their co-localization patterns. To capture both static and dynamic features of the data, we developed a novel inference method termed the generalized Glauber dynamics (GGD) that can tune the dynamics while keeping the steady state distribution fixed. I will first outline the explanation power of the GGD dynamics, then explain how to infer the dynamics from data. The inferred interactions characterize sociability for different mouse strains. In the second example, we studied information flow among neurons in the larval zebrafish hindbrain. By adapting the method of Granger causality to single cell calcium transient data, we were able to detect both a global information flow among neurons, as well as identifying brain regions that are key in locomotion.