Life cycle and metamorphosis of nanoparticles in the organism.- (Florence Gazeau/ CEMES / Seminar) – 24/11/2022, 11H

Les séminaires du jeudi

Florence Gazeau, Université Paris Cité, CNRS, Matière et Systèmes Complexes

Lien zoom : https://cnrs.zoom.us/j/97061901449?pwd=dUFxOE91OW9SN2RtRlV1MW9BYWlyUT09

Résumé :Organic or inorganic nanoparticles, intentionally introduced into the organism for their therapeutic properties or unintentionally as pollutants, can persist in cellular compartments over the long term and undergo numerous transformations that modify their physical properties as well as their morphology and tissue localisation. The links between the biotransformations (degradation, elimination, recycling by endogenous proteins, recrystallisation, biomineralisation) carried out by the biological environment on nanoparticles, their functionalities for diagnostic or therapeutic use and their potential short- or long-term toxicity remain poorly understood. We will give several examples of intracellular biotransformations of metallic (iron oxide, gold, silver, titanium) or carbonaceous (carbon nanotubes) nanoparticles that show unexpected effects and shed light on the life cycle of nanoparticles. In particular, we will illustrate the essential contribution of the various electron microscopy or nanometrology techniques for monitoring the fate of these nanostructures in a biological environment.